People With Spinal Injuries Are Regaining Use of Their Limbs in an Amazing Way

Inside UCLA’s Neuroplasticity and Repair Laboratory

Brian Gomez has his  fingers wrapped around a small bar attached to three short springs in a rectangular metal frame. It’s similar to the handlebar brake lever of a dirt bike, like the one Gomez was riding in 2011 that malfunctioned, causing a crash that left him paralyzed below the neck. He’s trying to close his hand, but the bar doesn’t budge. Then a switch is flipped, and tiny electrodes implanted on his spinal cord begin firing. “It’s like a fluid shock going through” his body, he says. Gomez straightens in his wheelchair. His forearm twitches, and his grip tightens. The metal bar moves.

Twenty-nine years old with long, dark sideburns, Gomez is in a gadget-packed lab at UCLA, with wires and sensors taped to his arm and neck as a team of neuroscience researchers is recording the force he’s able to exert when the electrodes are activated. It’s an experimental treatment to restore mobility in people who’ve been paralyzed, led by Daniel Lu, an associate professor of neurosurgery and director of the university’s Neuroplasticity and Repair Laboratory. “A lot of people think that after a spinal cord injury the function is not recoverable and the patient will be relegated to a life of dependency,” Lu says. “In the past maybe five years or so we’ve come to realize that that’s not the case…. Actually, the spinal cord has a lot of capacity within itself for processing ability.”

With spinal injuries, the body loses voluntary control over functions below the point of trauma. Damage the spinal cord in the lower back, and your legs are affected; damage it in the neck area, and functionality is limited for everything from there down. Lu’s approach, which builds on more than 40 years of research by UCLA neuroscientist V. Reggie Edgerton, redraws neural connections in the damaged area, essentially reminding the cord of what it once did. “It’s retraining that circuit to work again,” says Lu. When the electrodes are turned off, it can still remember.

Researchers are also developing robotically controlled exoskeleton devices to move disabled limbs, and a clinical trial will soon test a chip implant that allows direct brain control of a computer interface. These are promising treatments for the most extreme cases of paralysis, but Lu notes that the majority of injured cords aren’t completely severed. A lingering cellular connection means that repair is possible and ability can be regained through the targeted use of electrode stimulation, as with Gomez.

Lu has applied this treatment to three other patients, and a study for the National Institutes of Health is under way to prove that the method is safe for wider use. Since Gomez began training with the device nearly three years ago, his gripping strength when it’s on has gone from less than 1 newton of force to an average of 22 newtons, enough to crack an egg. Even without stimulation, his capability is up more than 300 percent. Lu expects to see further improvement as the study continues. “There may be a limit,” he says, “but we haven’t reached it yet.”

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